› 4oni

X-ray diffraction
1.8Å resolution

Structure of Human Orphan Receptor LRH1 bound to two bacterial phospholipids

Released:
DOI: 10.2210/pdb4oni/pdb
PDB entry 4oni coloured by chain, front view.
PDB entry 4oni coloured by chain, side view.
PDB entry 4oni coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gorman MA, Parker MW, Kusumo S

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126309 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor subfamily 5 group A member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 253 amino acids
Theoretical weight: 29.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00482 (Residues: 291-541; Coverage: 46%)
Gene names: B1F, CPF, FTF, NR5A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor subfamily 0 group B member 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 19 amino acids
Theoretical weight: 1.95 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15466 (Residues: 12-30; Coverage: 7%)
Gene names: NR0B2, SHP

Ligands and Environments

4 bound ligands:
Ligand EPH 1 x EPH
Ligand GOL 3 x GOL
Ligand P6L 1 x P6L
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 63.867Å b: 59.856Å c: 73.94Å
α: 90° β: 93.86° γ: 90°
R-values:
R R work R free
0.158 0.156 0.202
Expression systems:
  • Escherichia coli
  • Not provided

Quick links