› 4ono

X-ray diffraction
2.7Å resolution

CD1c in complex with PM (phosphomycoketide)

Released:
DOI: 10.2210/pdb4ono/pdb
PDB entry 4ono coloured by chain, front view.
PDB entry 4ono coloured by chain, side view.
PDB entry 4ono coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells.
Roy S, Ly D, Li NS, Altman JD, Piccirilli JA, Moody DB, Adams EJ
Proc Natl Acad Sci U S A 111 E4648-57 (2014)
PMID: 25298532

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151321 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Beta-2-microglobulin; T-cell surface glycoprotein CD1b; T-cell surface glycoprotein CD1c Chain: A
Molecule details ›
Chain: A
Length: 395 amino acids
Theoretical weight: 44.33 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
  • Canonical: P29016 (Residues: 19-20, 126-126, 204-258, 264-295; Coverage: 29%)
  • Canonical: P29017 (Residues: 26-125, 127-204, 260-264; Coverage: 58%)
Gene names: B2M, CD1B, CD1C, CDABP0092, HDCMA22P
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand PMK 1 x PMK
Ligand CL 6 x CL
Ligand MLI 3 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 54.312Å b: 86.978Å c: 89.574Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.219 0.271
Expression system: Spodoptera frugiperda

Quick links

Citations

23 review citations

Lipid and small-molecule display by CD1 and MR1.
Van Rhijn et al. (2015)
22 more

4 mentions without citation

The T cell antigen receptor: the Swiss army knife of the immune system.
Attaf et al. (2015)
3 more