Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-208916 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tyrosine-protein kinase HCK
Molecule details ›
Chain: A
Length: 67 amino acids
Theoretical weight: 7.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Length: 67 amino acids
Theoretical weight: 7.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P08631 (Residues: 77-138; Coverage: 12%)
Sequence domains: SH3 domain
Structure domains: SH3 Domains
C-terminal core protein
Molecule details ›
Chain: B
Length: 145 amino acids
Theoretical weight: 16.82 KDa
Source organism: HIV-1 M:B_ARV2/SF2
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Negative factor, (F-Protein) or Nef
Structure domains: Nef Regulatory Factor
Length: 145 amino acids
Theoretical weight: 16.82 KDa
Source organism: HIV-1 M:B_ARV2/SF2
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P03407 (Residues: 45-210; Coverage: 69%)
Sequence domains: Negative factor, (F-Protein) or Nef
Structure domains: Nef Regulatory Factor
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SLS BEAMLINE X10SA
Spacegroup:
P41
Expression system: Escherichia coli BL21(DE3)
