› 4oy9

X-ray diffraction
1.62Å resolution

Crystal structure of human P-Cadherin EC1-EC2 in closed conformation

Released:
DOI: 10.2210/pdb4oy9/pdb
PDB entry 4oy9 coloured by chain, front view.
PDB entry 4oy9 coloured by chain, side view.
PDB entry 4oy9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The X-ray structure of human P-cadherin EC1-EC2 in a closed conformation provides insight into the type I cadherin dimerization pathway.
Dalle Vedove A, Lucarelli AP, Nardone V, Matino A, Parisini E
Acta Crystallogr F Struct Biol Commun 71 371-80 (2015)
PMID: 25849494

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149552 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-3 Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 23.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22223 (Residues: 108-320; Coverage: 27%)
Gene names: CDH3, CDHP
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 75.381Å b: 40.949Å c: 72.409Å
α: 90° β: 98.05° γ: 90°
R-values:
R R work R free
0.165 0.163 0.202
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 citation in other articles

Adhesive Dimerization of Human P-Cadherin Catalyzed by a Chaperone-like Mechanism.
Kudo et al. (2016)
6 more

1 mention without citation

The X-ray structure of human P-cadherin EC1-EC2 in a closed conformation provides insight into the type I cadherin dimerization pathway.
Dalle Vedove et al. (2015)