› 4oys

X-ray diffraction
2.9Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185509 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase catalytic subunit type 3 Chain: A
Molecule details ›
Chain: A
Length: 601 amino acids
Theoretical weight: 68.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8NEB9 (Residues: 282-879; Coverage: 67%)
Gene names: PIK3C3, VPS34
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand 1TT 1 x 1TT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21212
Unit cell:
a: 89.81Å b: 145.7Å c: 61.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.18 0.248
Expression system: Escherichia coli BL21

Quick links

Citations

110 review citations

Mechanism and medical implications of mammalian autophagy.
Dikic et al. (2018)
109 more

8 mentions without citation

VPS34 complexes from a structural perspective.
Ohashi et al. (2019)
7 more