› 4p0j

X-ray diffraction
2.3Å resolution

Crystal Structure of Loop-Swapped Interleukin-36Ra

Released:
DOI: 10.2210/pdb4p0j/pdb
PDB entry 4p0j coloured by chain, front view.
PDB entry 4p0j coloured by chain, side view.
PDB entry 4p0j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor.
Günther S, Sundberg EJ
J Immunol 193 921-30 (2014)
PMID: 24935927

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192743 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-36 gamma; Interleukin-36 receptor antagonist protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 150 amino acids
Theoretical weight: 16.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UBH0 (Residues: 2-138, 148-155; Coverage: 92%)
  • Canonical: Q9NZH8 (Residues: 155-161; Coverage: 4%)
Gene names: FIL1D, IL1E, IL1F5, IL1F9, IL1H1, IL1HY1, IL1L1, IL1RP2, IL1RP3, IL36G, IL36RN, UNQ1896/PRO4342, UNQ2456/PRO5737
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P1
Unit cell:
a: 41.414Å b: 41.549Å c: 50.841Å
α: 97.89° β: 102.26° γ: 118.46°
R-values:
R R work R free
0.211 0.21 0.239
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

The family of the interleukin-1 receptors.
Boraschi et al. (2018)
15 more

2 mentions without citation

Structural Basis of IL-1 Family Cytokine Signaling.
Fields et al. (2019)
1 more