› 4p2k

X-ray diffraction
1.5Å resolution

Structure of Ephrin type-A receptor 2

Released:
DOI: 10.2210/pdb4p2k/pdb
PDB entry 4p2k coloured by chain, front view.
PDB entry 4p2k coloured by chain, side view.
PDB entry 4p2k coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Jimin Z, Qiang W, Nan W

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29317 (Residues: 590-876; Coverage: 30%)
Gene names: ECK, EPHA2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P212121
Unit cell:
a: 54.885Å b: 74.796Å c: 76.019Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.19
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases.
Xu et al. (2015)