› 4p39

X-ray diffraction
2.4Å resolution

Crystal structure of the human C5aR antagonist C5a-A8

Released:
DOI: 10.2210/pdb4p39/pdb
PDB entry 4p39 coloured by chain, front view.
PDB entry 4p39 coloured by chain, side view.
PDB entry 4p39 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional characterization of human and murine C5a anaphylatoxins.
Schatz-Jakobsen JA, Yatime L, Larsen C, Petersen SV, Klos A, Andersen GR
Acta Crystallogr D Biol Crystallogr 70 1704-17 (2014)
PMID: 24914981

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-133860 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C5a anaphylatoxin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 77 amino acids
Theoretical weight: 8.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01031 (Residues: 678-747; Coverage: 4%)
Gene names: C5, CPAMD4
Sequence domains: Anaphylotoxin-like domain
Structure domains: Anaphylotoxins (complement system)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2221
Unit cell:
a: 69.35Å b: 83.24Å c: 119.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.224 0.238
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
5 more

3 mentions without citation

Structural and functional characterization of human and murine C5a anaphylatoxins.
Schatz-Jakobsen et al. (2014)
2 more