› 4p3w

X-ray diffraction
2Å resolution

Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide

Released:
DOI: 10.2210/pdb4p3w/pdb
PDB entry 4p3w coloured by chain, front view.
PDB entry 4p3w coloured by chain, side view.
PDB entry 4p3w coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Seppala J, Pentikainen U, Ylanne J

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149205 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Filamin-A Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 182 amino acids
Theoretical weight: 19.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P21333 (Residues: 2152-2329; Coverage: 7%)
Gene names: FLN, FLN1, FLNA
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins
Filamin-binding LIM protein 1 Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 24 amino acids
Theoretical weight: 2.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8WUP2 (Residues: 5-28; Coverage: 6%)
Gene names: FBLIM1, FBLP1

Ligands and Environments

3 bound ligands:
Ligand SO4 4 x SO4
Ligand PR 4 x PR
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: R3
Unit cell:
a: 88.154Å b: 88.154Å c: 394.709Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.2 0.226
Expression systems:
  • Escherichia coli BL21
  • Not provided

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