› 4p42

X-ray diffraction
2.44Å resolution

Extended-Synaptotagmin 2, SMP - C2A - C2B Domains

Released:
DOI: 10.2210/pdb4p42/pdb
PDB entry 4p42 coloured by chain, front view.
PDB entry 4p42 coloured by chain, side view.
PDB entry 4p42 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.
Schauder CM, Wu X, Saheki Y, Narayanaswamy P, Torta F, Wenk MR, De Camilli P, Reinisch KM
Nature 510 552-5 (2014)
PMID: 24847877

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106073 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Extended synaptotagmin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 474 amino acids
Theoretical weight: 54.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: A0FGR8 (Residues: 191-662; Coverage: 51%)
Gene names: ESYT2, FAM62B, KIAA1228
Sequence domains:
Structure domains: C2 domain

Ligands and Environments

2 bound ligands:
Ligand EGC 2 x EGC
Ligand PEE 2 x PEE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 74.332Å b: 88.382Å c: 167.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.256
Expression system: Escherichia coli K-12

Quick links

Citations

73 review citations

Structure and function of ER membrane contact sites with other organelles.
Phillips et al. (2016)
72 more

19 mentions without citation

SMP-domain proteins at membrane contact sites: Structure and function.
Reinisch et al. (2016)
18 more