4p5k

X-ray diffraction
2.59Å resolution

Structural Basis of Chronic Beryllium Disease: Bridging the Gap Between Allergy and Autoimmunity

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-137850 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HLA class II histocompatibility antigen, DP alpha 1 chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 183 amino acids
Theoretical weight: 21.17 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P20036 (Residues: 32-214; Coverage: 79%)
Gene names: HLA-DP1A, HLA-DPA1, HLASB
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DP beta 1 chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 212 amino acids
Theoretical weight: 24.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04440 (Residues: 11-14, 32-218; Coverage: 75%)
Gene names: HLA-DP1B, HLA-DPB1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: C2
Unit cell:
a: 182.779Å b: 68.738Å c: 71.133Å
α: 90° β: 105.72° γ: 90°
R-values:
R R work R free
0.224 0.221 0.281
Expression system: Spodoptera frugiperda