› 4pbx

X-ray diffraction
3.15Å resolution

Crystal structure of the six N-terminal domains of human receptor protein tyrosine phosphatase sigma

Released:
DOI: 10.2210/pdb4pbx/pdb
PDB entry 4pbx coloured by chain, front view.
PDB entry 4pbx coloured by chain, side view.
PDB entry 4pbx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.
Coles CH, Mitakidis N, Zhang P, Elegheert J, Lu W, Stoker AW, Nakagawa T, Craig AM, Jones EY, Aricescu AR
Nat Commun 5 5209 (2014)
PMID: 25385546

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171644 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase S Chain: A
Molecule details ›
Chain: A
Length: 584 amino acids
Theoretical weight: 64.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13332 (Residues: 30-614; Coverage: 30%)
Gene name: PTPRS
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P6122
Unit cell:
a: 198.78Å b: 198.78Å c: 132.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.234 0.265
Expression system: Homo sapiens

Quick links

Citations

15 review citations

Spatial and temporal arrangement of neuronal intrinsic and extrinsic mechanisms controlling axon regeneration.
Tedeschi et al. (2017)
14 more

7 mentions without citation

Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.
Coles et al. (2015)
6 more