› 4pme

X-ray diffraction
1.26Å resolution

Human transthyretin (TTR) complexed with ferulic acid and curcumin.

Released:
DOI: 10.2210/pdb4pme/pdb
PDB entry 4pme coloured by chain, front view.
PDB entry 4pme coloured by chain, side view.
PDB entry 4pme coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures.
Ciccone L, Tepshi L, Nencetti S, Stura EA
N Biotechnol 32 54-64 (2015)
PMID: 25224922

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 12.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 29-146; Coverage: 93%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

4 bound ligands:
Ligand CUR 1 x CUR
Ligand NA 1 x NA
Ligand EDO 1 x EDO
Ligand FER 2 x FER
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 42.99Å b: 84.67Å c: 64.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.207

Quick links

Citations

3 review citations

The Essential Medicinal Chemistry of Curcumin.
Nelson et al. (2017)
2 more

2 mentions without citation

Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: analysis of structural data for future drug design.
Ciccone et al. (2020)
1 more