› 4po6

X-ray diffraction
1.99Å resolution

Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide

Released:
DOI: 10.2210/pdb4po6/pdb
PDB entry 4po6 coloured by chain, front view.
PDB entry 4po6 coloured by chain, side view.
PDB entry 4po6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of IFN receptor recognition by TYK2
Wallweber HJA, Tam C, Franke Y, Starovasnik MA, Lupardus PJ
Nat. Struct. Mol. Biol. (2014)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147891 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Non-receptor tyrosine-protein kinase TYK2 Chain: A
Molecule details ›
Chain: A
Length: 567 amino acids
Theoretical weight: 63.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29597 (Residues: 23-583; Coverage: 47%)
Gene name: TYK2
Sequence domains:
Interferon alpha/beta receptor 1 Chain: B
Molecule details ›
Chain: B
Length: 34 amino acids
Theoretical weight: 3.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P17181 (Residues: 478-507; Coverage: 6%)
Gene names: IFNAR, IFNAR1

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: C2
Unit cell:
a: 186.768Å b: 52.422Å c: 70.163Å
α: 90° β: 108.09° γ: 90°
R-values:
R R work R free
0.201 0.199 0.234
Expression system: Spodoptera frugiperda

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