› 4pr9

X-ray diffraction
3.2Å resolution

Human Vinculin (residues 891-1066) in complex with PIP

Released:
DOI: 10.2210/pdb4pr9/pdb
PDB entry 4pr9 coloured by chain, front view.
PDB entry 4pr9 coloured by chain, side view.
PDB entry 4pr9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chinthalapudi K, Rangarajan ES, Patil D, Izard T

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148327 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vinculin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 176 amino acids
Theoretical weight: 19.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18206 (Residues: 962-1134; Coverage: 15%)
Gene name: VCL
Sequence domains: Vinculin family
Structure domains: Alpha-catenin/vinculin-like

Ligands and Environments

2 bound ligands:
Ligand PIO 3 x PIO
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3212
Unit cell:
a: 102.579Å b: 102.579Å c: 190.772Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.25
Expression system: Escherichia coli

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