4prh

X-ray diffraction
2.5Å resolution

Crystal structure of TK3 TCR-HLA-B*35:08-HPVG-D5 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-111515 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 31.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: C5MK56 (Residues: 26-299; Coverage: 81%)
Gene name: HLA-B
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 23-119; Coverage: 98%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Epstein-Barr nuclear antigen 1 Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.31 KDa
Source organism: human gammaherpesvirus 4
Expression system: Not provided
UniProt:
  • Canonical: Q3KSS4 (Residues: 407-417; Coverage: 2%)
Gene names: BKRF1, EBNA1
T cell receptor alpha chain constant Chain: D
Molecule details ›
Chain: D
Length: 208 amino acids
Theoretical weight: 23.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01848 (Residues: 1-93; Coverage: 66%)
Gene names: TCRA, TRAC
Sequence domains: Domain of unknown function (DUF1968)
Structure domains: Immunoglobulins
T cell receptor beta constant 1 Chain: E
Molecule details ›
Chain: E
Length: 243 amino acids
Theoretical weight: 27.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01850 (Residues: 1-129; Coverage: 73%)
Gene name: TRBC1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P1
Unit cell:
a: 44.835Å b: 62.081Å c: 98.334Å
α: 92.7° β: 101.92° γ: 108.21°
R-values:
R R work R free
0.214 0.212 0.253
Expression systems:
  • Escherichia coli
  • Not provided