› 4ptb

X-ray diffraction
1.6Å resolution

Crystal structure of human SP100 PHD-Bromodomain in the free state

Released:
DOI: 10.2210/pdb4ptb/pdb
PDB entry 4ptb coloured by chain, front view.
PDB entry 4ptb coloured by chain, side view.
PDB entry 4ptb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tallant C, Nunez-Alonso G, Savitsky P, Newman J, Krojer T, Szykowska A, Burgess-Brown N, Filippakopoulos P, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149985 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear autoantigen Sp-100 Chains: A, B
Molecule details ›
Chains: A, B
Length: 180 amino acids
Theoretical weight: 21.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23497 (Residues: 466-498, 499-508; Coverage: 5%)
Gene name: SP100
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand MES 1 x MES
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 127.52Å b: 45.183Å c: 83.188Å
α: 90° β: 102.21° γ: 90°
R-values:
R R work R free
0.174 0.173 0.192
Expression system: Escherichia coli

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