› 4pvg

X-ray diffraction
2.4Å resolution

Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79

Released:
DOI: 10.2210/pdb4pvg/pdb
PDB entry 4pvg coloured by chain, front view.
PDB entry 4pvg coloured by chain, side view.
PDB entry 4pvg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhang Z-Y, Zeng L, Liu D, Yu Z

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170287 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 11 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 34.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06124 (Residues: 240-528; Coverage: 49%)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand 2WT 1 x 2WT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P1
Unit cell:
a: 40.031Å b: 40.921Å c: 48.934Å
α: 94.58° β: 109.19° γ: 109.95°
R-values:
R R work R free
0.236 0.236 0.286
Expression system: Escherichia coli

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