› 4pwj

X-ray diffraction
1.55Å resolution

Crystal structure of V30M mutant human transthyretin complexed with nordihydroguaiaretic acid

Released:
DOI: 10.2210/pdb4pwj/pdb
PDB entry 4pwj coloured by chain, front view.
PDB entry 4pwj coloured by chain, side view.
PDB entry 4pwj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin.
Yokoyama T, Kosaka Y, Mizuguchi M
J Med Chem 57 8928-35 (2014)
PMID: 25314129

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 159 amino acids
Theoretical weight: 17.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 1-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand 30Z 2 x 30Z
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21212
Unit cell:
a: 43.565Å b: 85.391Å c: 64.221Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.219
Expression system: Escherichia coli

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Citations

6 review citations

The A-Z of Zika drug discovery.
Mottin et al. (2018)
5 more

1 mention without citation

Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: analysis of structural data for future drug design.
Ciccone et al. (2020)