› 4pxs

X-ray diffraction
2.6Å resolution

Human GKRP bound to AMG-0265 (N-[(R)-(2-CHLOROPHENYL){7-[4-(2-HYDROXYPROPAN-2-YL) PYRIDIN-2-YL]-1-BENZOTHIOPHEN-2-YL}METHYL]CYCLOPROPANESULFONAMIDE) and Sorbitol-6-phosphate

Released:
DOI: 10.2210/pdb4pxs/pdb
PDB entry 4pxs coloured by chain, front view.
PDB entry 4pxs coloured by chain, side view.
PDB entry 4pxs coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Jordan SR, Chmait S

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171997 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucokinase regulatory protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 638 amino acids
Theoretical weight: 70.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14397 (Residues: 1-625; Coverage: 100%)
Gene name: GCKR
Sequence domains: C-terminal lid domain of glucokinase regulatory protein
Structure domains: Glucose-6-phosphate isomerase like protein; domain 1

Ligands and Environments

5 bound ligands:
Ligand 2Y6 2 x 2Y6
Ligand S6P 2 x S6P
Ligand IOD 29 x IOD
Ligand GOL 2 x GOL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P65
Unit cell:
a: 148.63Å b: 148.63Å c: 133.622Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.238 0.234 0.307
Expression system: Spodoptera frugiperda

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