› 4pxw

X-ray diffraction
1.72Å resolution

Crystal structure of human DCAF1 WD40 repeats (Q1250L)

Released:
DOI: 10.2210/pdb4pxw/pdb
PDB entry 4pxw coloured by chain, front view.
PDB entry 4pxw coloured by chain, side view.
PDB entry 4pxw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Xu C, Tempel W, He H, Li Y, Walker JR, Bountra C, Arrowsmith CH, Edwards AM, Min J, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DDB1- and CUL4-associated factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 381 amino acids
Theoretical weight: 43.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y4B6 (Residues: 1039-1401; Coverage: 24%)
Gene names: DCAF1, KIAA0800, RIP, VPRBP
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

1 bound ligand:
Ligand UNX 45 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 74.888Å b: 99.422Å c: 84.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.183 0.219
Expression system: Spodoptera frugiperda

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