› 4pyp

X-ray diffraction
3.17Å resolution

Crystal structure of the human glucose transporter GLUT1

Released:
DOI: 10.2210/pdb4pyp/pdb
PDB entry 4pyp coloured by chain, front view.
PDB entry 4pyp coloured by chain, side view.
PDB entry 4pyp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human glucose transporter GLUT1.
Deng D, Xu C, Sun P, Wu J, Yan C, Hu M, Yan N
Nature 510 121-5 (2014)
PMID: 24847886

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145688 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 2, facilitated glucose transporter member 1 Chain: A
Molecule details ›
Chain: A
Length: 504 amino acids
Theoretical weight: 55.74 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P11166 (Residues: 1-492; Coverage: 100%)
Gene names: GLUT1, SLC2A1
Sequence domains: Sugar (and other) transporter
Structure domains: MFS general substrate transporter like domains

Ligands and Environments

1 bound ligand:
Ligand BNG 1 x BNG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 120.509Å b: 101.996Å c: 65.604Å
α: 90° β: 101.27° γ: 90°
R-values:
R R work R free
0.234 0.232 0.278
Expression system: Trichoplusia ni

Quick links

Citations

89 review citations

Blood-Brain Barrier: From Physiology to Disease and Back.
Sweeney et al. (2019)
88 more

89 mentions without citation

GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters.
Deng et al. (2016)
88 more