› 4pz4

X-ray diffraction
1.6Å resolution

High-resolution crystal structure of the human CD44 hyaluronan binding domain in new space group

Released:
DOI: 10.2210/pdb4pz4/pdb
PDB entry 4pz4 coloured by chain, front view.
PDB entry 4pz4 coloured by chain, side view.
PDB entry 4pz4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction.
Liu LK, Finzel B
Acta Crystallogr F Struct Biol Commun 70 1155-61 (2014)
PMID: 25195884

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147592 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD44 antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 154 amino acids
Theoretical weight: 17.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16070 (Residues: 18-171; Coverage: 21%)
Gene names: CD44, LHR, MDU2, MDU3, MIC4
Sequence domains: Extracellular link domain

Ligands and Environments

5 bound ligands:
Ligand SO4 6 x SO4
Ligand PEG 4 x PEG
Ligand GOL 1 x GOL
Ligand EDO 4 x EDO
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P6122
Unit cell:
a: 70.271Å b: 70.271Å c: 286.458Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.197 0.229
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Revealing the Mechanisms of Protein Disorder and N-Glycosylation in CD44-Hyaluronan Binding Using Molecular Simulation.
Guvench O. (2015)
1 more

4 mentions without citation

High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction.
Liu et al. (2014)
3 more