› 4q0n

X-ray diffraction
1.78Å resolution

Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand

Released:
DOI: 10.2210/pdb4q0n/pdb
PDB entry 4q0n coloured by chain, front view.
PDB entry 4q0n coloured by chain, side view.
PDB entry 4q0n coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Picaud S, Felletar I, Martin S, Monteiro O, Fedorov O, Chaikuad A, Yue W, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183177 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein polybromo-1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 145 amino acids
Theoretical weight: 17.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86U86 (Residues: 645-766; Coverage: 7%)
Gene names: BAF180, PB1, PBRM1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand EDO 9 x EDO
Ligand 2XD 8 x 2XD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 42.021Å b: 136.722Å c: 114.413Å
α: 90° β: 91.4° γ: 90°
R-values:
R R work R free
0.176 0.176 0.214
Expression system: Escherichia coli

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