› 4q26

X-ray diffraction
1.4Å resolution

Crystal Structure of Galectin-1 in Complex with N-Acetyllactosamine

Released:
DOI: 10.2210/pdb4q26/pdb
PDB entry 4q26 coloured by chain, front view.
PDB entry 4q26 coloured by chain, side view.
PDB entry 4q26 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Grimm C, Bertleff-Zieschang N

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-1 Chains: A, B, G, H
Molecule details ›
Chains: A, B, G, H
Length: 136 amino acids
Theoretical weight: 15.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09382 (Residues: 1-135; Coverage: 100%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NDG, GAL
Carbohydrate polymer
1 bound ligand:
Ligand GOL 1 x GOL
1 modified residue:
Ligand CME 12 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 66.384Å b: 85.517Å c: 116.076Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.162 0.203
Expression system: Escherichia coli

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