Function and Biology Details
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-148949 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Rab5 GDP/GTP exchange factor
Molecule details ›
Chains: A, E
Length: 317 amino acids
Theoretical weight: 37.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 317 amino acids
Theoretical weight: 37.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9UJ41 (Residues: 132-455; Coverage: 63%)
Sequence domains:
Ras-related protein Rab-5A
Molecule details ›
Chains: B, F
Length: 171 amino acids
Theoretical weight: 19.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ras family
Length: 171 amino acids
Theoretical weight: 19.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P20339 (Residues: 15-184; Coverage: 79%)
Sequence domains: Ras family
Rab GTPase-binding effector protein 1
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRF BEAMLINE BL17U
Spacegroup:
P41212
Expression system: Escherichia coli
