› 4q9v

X-ray diffraction
2.3Å resolution

Crystal structure of TIPE3

Released:
DOI: 10.2210/pdb4q9v/pdb
PDB entry 4q9v coloured by chain, front view.
PDB entry 4q9v coloured by chain, side view.
PDB entry 4q9v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TIPE3 is the transfer protein of lipid second messengers that promote cancer.
Fayngerts SA, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T, Wang Z, Cui J, Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH
Cancer Cell 26 465-78 (2014)
PMID: 25242044

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177148 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor alpha-induced protein 8-like protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 186 amino acids
Theoretical weight: 21.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5GJ75 (Residues: 109-292; Coverage: 63%)
Gene names: TIPE3, TNFAIP8L3
Sequence domains: Domain of unknown function (DUF758)
Structure domains: Tumor necrosis factor alpha-induced protein 8-like

Ligands and Environments

2 bound ligands:
Ligand CL 5 x CL
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: I222
Unit cell:
a: 61.729Å b: 87.296Å c: 242.309Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.24 0.262
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor.
Yan et al. (2019)
10 more

6 mentions without citation

Phospholipid regulation of the nuclear receptor superfamily.
Crowder et al. (2017)
5 more