› 4qdr

X-ray diffraction
2.4Å resolution

Physical basis for Nrp2 ligand binding

Released:
DOI: 10.2210/pdb4qdr/pdb
PDB entry 4qdr coloured by chain, front view.
PDB entry 4qdr coloured by chain, side view.
PDB entry 4qdr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.
Parker MW, Linkugel AD, Goel HL, Wu T, Mercurio AM, Vander Kooi CW
Structure 23 677-87 (2015)
PMID: 25752543

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuropilin-2 Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 36.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60462 (Residues: 276-595; Coverage: 35%)
Gene names: NRP2, VEGF165R2
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 34.901Å b: 70.759Å c: 122.974Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.255
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy.
Roy et al. (2017)
16 more

1 mention without citation

Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.
Parker et al. (2015)