› 4qe8

X-ray diffraction
2.62Å resolution

FXR with DM175 and NCoA-2 peptide

Released:
DOI: 10.2210/pdb4qe8/pdb
PDB entry 4qe8 coloured by chain, front view.
PDB entry 4qe8 coloured by chain, side view.
PDB entry 4qe8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kudlinzki D, Merk D, Linhard VL, Saxena K, Sreeramulu S, Nilsson E, Dekker N, Wissler L, Bamberg K, Schubert-Zsilavecz M, Schwalbe H

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172333 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bile acid receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 233 amino acids
Theoretical weight: 27.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96RI1 (Residues: 258-486; Coverage: 47%)
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.59 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 740-752; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

3 bound ligands:
Ligand 31D 2 x 31D
Ligand EDO 7 x EDO
Ligand MRD 1 x MRD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P1
Unit cell:
a: 34.483Å b: 48.683Å c: 82.201Å
α: 88.89° β: 78.1° γ: 85.07°
R-values:
R R work R free
0.252 0.249 0.273
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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