› 4qft

X-ray diffraction
1.76Å resolution

Structure of COP9 signalosome complex subunit 6

Released:
DOI: 10.2210/pdb4qft/pdb
PDB entry 4qft coloured by chain, front view.
PDB entry 4qft coloured by chain, side view.
PDB entry 4qft coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer.
Birol M, Enchev RI, Padilla A, Stengel F, Aebersold R, Betzi S, Yang Y, Hoh F, Peter M, Dumas C, Echalier A
PLoS One 9 e105688 (2014)
PMID: 25144743

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-181633 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
COP9 signalosome complex subunit 6 Chain: A
Molecule details ›
Chain: A
Length: 186 amino acids
Theoretical weight: 20.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7L5N1 (Residues: 31-211; Coverage: 55%)
Gene names: COPS6, CSN6, HVIP
Sequence domains: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Structure domains: Cytidine Deaminase, domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3121
Unit cell:
a: 96.838Å b: 96.838Å c: 48.333Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.155 0.153 0.206
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Mechanisms of Deubiquitinase Specificity and Regulation.
Mevissen et al. (2017)
8 more

1 mention without citation

Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer.
Birol et al. (2014)