Function and Biology Details
Reaction catalysed:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Guanine nucleotide binding protein (G-protein), alpha subunit
- Phosphoinositide phospholipase C family
- G-protein alpha subunit, group Q
- C2 domain
- C2 domain superfamily
- Phospholipase C, phosphatidylinositol-specific, Y domain
- Phosphatidylinositol-specific phospholipase C, X domain
- PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
5 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149200 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Guanine nucleotide-binding protein G(q) subunit alpha
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 44.71 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
Sequence domains: G-protein alpha subunit
Structure domains:
Length: 379 amino acids
Theoretical weight: 44.71 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P21279 (Residues: 7-359; Coverage: 98%)
Sequence domains: G-protein alpha subunit
Structure domains:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Molecule details ›
Chain: B
Length: 793 amino acids
Theoretical weight: 90.29 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 793 amino acids
Theoretical weight: 90.29 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: Q01970 (Residues: 10-891; Coverage: 64%)
Sequence domains:
- PH domain
- Phosphoinositide-specific phospholipase C, efhand-like
- Phosphatidylinositol-specific phospholipase C, X domain
- Phosphatidylinositol-specific phospholipase C, Y domain
- C2 domain
