› 4qmd

X-ray diffraction
1.6Å resolution

Crystal structure of human envoplakin plakin repeat domain

Released:
DOI: 10.2210/pdb4qmd/pdb
PDB entry 4qmd coloured by chain, front view.
PDB entry 4qmd coloured by chain, side view.
PDB entry 4qmd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin.
Fogl C, Mohammed F, Al-Jassar C, Jeeves M, Knowles TJ, Rodriguez-Zamora P, White SA, Odintsova E, Overduin M, Chidgey M
Nat Commun 7 10827 (2016)
PMID: 26935805

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187763 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envoplakin Chains: A, B
Molecule details ›
Chains: A, B
Length: 193 amino acids
Theoretical weight: 21.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92817 (Residues: 1822-2014; Coverage: 10%)
Gene name: EVPL
Sequence domains: Plectin repeat
Structure domains: Plakin repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 42.48Å b: 68.95Å c: 112.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.168 0.205
Expression system: Escherichia coli

Quick links

Citations

5 review citations

LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis.
Tang et al. (2018)
4 more

3 mentions without citation

Recent insight into intermediate filament structure.
Eldirany et al. (2021)
2 more