› 4qmi

X-ray diffraction
1.9Å resolution

The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array

Released:
DOI: 10.2210/pdb4qmi/pdb
PDB entry 4qmi coloured by chain, front view.
PDB entry 4qmi coloured by chain, side view.
PDB entry 4qmi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array.
Fox JC, Howard AE, Currie JD, Rogers SL, Slep KC
Mol Biol Cell 25 2375-92 (2014)
PMID: 24966168

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171898 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoskeleton-associated protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 240 amino acids
Theoretical weight: 26.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14008 (Residues: 846-1081; Coverage: 12%)
Gene names: CKAP5, KIAA0097
Sequence domains: CLASP N terminal
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 64.418Å b: 74.293Å c: 93.684Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.174 0.215
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Control of microtubule organization and dynamics: two ends in the limelight.
Akhmanova et al. (2015)
5 more

3 mentions without citation

The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array.
Fox et al. (2014)
2 more