› 4qpf

X-ray diffraction
1.59Å resolution

New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption

Released:
DOI: 10.2210/pdb4qpf/pdb
PDB entry 4qpf coloured by chain, front view.
PDB entry 4qpf coloured by chain, side view.
PDB entry 4qpf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ebetino FH, Lundy M, Kwaasi AA, Dunford JE, Duan Z, Triffitt J, Mazur A, Jeans G, Barnett BL, Russell RGG

Function and Biology Details

Reactions catalysed: 
Prenyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146902 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase Chain: A
Molecule details ›
Chain: A
Length: 375 amino acids
Theoretical weight: 43.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14324 (Residues: 67-419; Coverage: 84%)
Gene names: FDPS, FPS, KIAA1293
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

2 bound ligands:
Ligand 39L 1 x 39L
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P41212
Unit cell:
a: 112.226Å b: 112.226Å c: 65.979Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.166 0.206
Expression system: Escherichia coli BL21(DE3)

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