› 4qss

X-ray diffraction
2Å resolution

Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with N-Methyl-2-pyrrolidone (NMP)

Released:
DOI: 10.2210/pdb4qss/pdb
PDB entry 4qss coloured by chain, front view.
PDB entry 4qss coloured by chain, side view.
PDB entry 4qss coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain
Chaikuad A, Petros AM, Fedorov O, Xu J, Knapp S
MedChemComm 5 1843-1848 (2014)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-180199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATPase family AAA domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 15.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6PL18 (Residues: 981-1108; Coverage: 9%)
Gene names: ATAD2, L16, PRO2000
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

4 bound ligands:
Ligand SO4 2 x SO4
Ligand MPD 3 x MPD
Ligand GOL 1 x GOL
Ligand MB3 1 x MB3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P6522
Unit cell:
a: 79.444Å b: 79.444Å c: 139.401Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.159 0.192
Expression system: Escherichia coli

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