› 4qxf

X-ray diffraction
2.25Å resolution

crystal structure of human LGR4 and Rspo1

Released:
DOI: 10.2210/pdb4qxf/pdb
PDB entry 4qxf coloured by chain, front view.
PDB entry 4qxf coloured by chain, side view.
PDB entry 4qxf coloured by chain, top view.
Source organisms:
Entry authors: Xu JG, Huang C, Zhou Y, Zhu Y

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173732 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
LRRNT domain-containing protein; Leucine-rich repeat-containing G-protein coupled receptor 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 301 amino acids
Theoretical weight: 33.15 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BXB1 (Residues: 27-253; Coverage: 25%)
  • Canonical: Q4G1L2 (Residues: 129-200; Coverage: 29%)
Gene names: GPR48, LGR4, VLRB
Sequence domains:
R-spondin-1 Chains: C, E
Molecule details ›
Chains: C, E
Length: 102 amino acids
Theoretical weight: 11.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q2MKA7 (Residues: 34-135; Coverage: 42%)
Gene name: RSPO1
Sequence domains: Furin-like repeat, cysteine-rich
Structure domains: Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 44.867Å b: 137.913Å c: 82.56Å
α: 90° β: 100.13° γ: 90°
R-values:
R R work R free
0.215 0.213 0.243
Expression system: Spodoptera frugiperda

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