› 4qxo

X-ray diffraction
1.88Å resolution

Crystal structure of hSTING(group2) in complex with DMXAA

Released:
DOI: 10.2210/pdb4qxo/pdb
PDB entry 4qxo coloured by chain, front view.
PDB entry 4qxo coloured by chain, side view.
PDB entry 4qxo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.
Gao P, Zillinger T, Wang W, Ascano M, Dai P, Hartmann G, Tuschl T, Deng L, Barchet W, Patel DJ
Cell Rep 8 1668-1676 (2014)
PMID: 25199835

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 188 amino acids
Theoretical weight: 21.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 155-341; Coverage: 49%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 1YE 1 x 1YE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6122
Unit cell:
a: 62.921Å b: 62.921Å c: 196.054Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.174 0.218
Expression system: Escherichia coli

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Citations

18 review citations

Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.
Kato et al. (2017)
17 more

3 mentions without citation

Host-pathogen protein-nucleic acid interactions: A comprehensive review.
Jain et al. (2022)
2 more