› 4r0u

X-ray diffraction
1.38Å resolution

Tgvtava, an amyloid forming segment from alpha synuclein, residues 72-78

Released:
DOI: 10.2210/pdb4r0u/pdb
PDB entry 4r0u coloured by chain, front view.
PDB entry 4r0u coloured by chain, side view.
PDB entry 4r0u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based design of functional amyloid materials.
Li D, Jones EM, Sawaya MR, Furukawa H, Luo F, Ivanova M, Sievers SA, Wang W, Yaghi OM, Liu C, Eisenberg DS
J Am Chem Soc 136 18044-51 (2014)
PMID: 25474758

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153502 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chain: A
Molecule details ›
Chain: A
Length: 7 amino acids
Theoretical weight: 618 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P37840 (Residues: 72-78; Coverage: 5%)
Gene names: NACP, PARK1, SNCA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P21
Unit cell:
a: 15.584Å b: 4.742Å c: 25.806Å
α: 90° β: 98.96° γ: 90°
R-values:
R R work R free
0.204 0.203 0.218
Expression system: Not provided

Quick links

Citations

4 review citations

Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology.
Wei et al. (2017)
3 more

4 mentions without citation

A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates.
Rajasekhar et al. (2016)
3 more