› 4r0x

X-ray diffraction
1.2Å resolution

Allosteric coupling of conformational transitions in the FK1 domain of FKBP51 near the site of steroid receptor interaction

Released:
DOI: 10.2210/pdb4r0x/pdb
PDB entry 4r0x coloured by chain, front view.
PDB entry 4r0x coloured by chain, side view.
PDB entry 4r0x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins.
LeMaster DM, Mustafi SM, Brecher M, Zhang J, Héroux A, Li H, Hernández G
J Biol Chem 290 15746-15757 (2015)
PMID: 25953903

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-171693 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP5 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13451 (Residues: 20-140; Coverage: 27%)
Gene names: AIG6, FKBP5, FKBP51
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2
Unit cell:
a: 69.435Å b: 31.99Å c: 57.435Å
α: 90° β: 119.03° γ: 90°
R-values:
R R work R free
0.159 0.159 0.167
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds.
Dunyak et al. (2016)
2 more

1 mention without citation

Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins.
LeMaster et al. (2015)