› 4r14

X-ray diffraction
2.6Å resolution

Crystal structure of human CSN6 MPN domain

Released:
DOI: 10.2210/pdb4r14/pdb
PDB entry 4r14 coloured by chain, front view.
PDB entry 4r14 coloured by chain, side view.
PDB entry 4r14 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human CSN6 MPN domain.
Ma XL, Xu M, Jiang T
Biochem Biophys Res Commun 453 25-30 (2014)
PMID: 25242525

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181634 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
COP9 signalosome complex subunit 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 181 amino acids
Theoretical weight: 20.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7L5N1 (Residues: 38-210; Coverage: 53%)
Gene names: COPS6, CSN6, HVIP
Sequence domains: JAB1/Mov34/MPN/PAD-1 ubiquitin protease

Ligands and Environments

1 bound ligand:
Ligand HG 8 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P32
Unit cell:
a: 66.552Å b: 66.552Å c: 86.829Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.225 0.259
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Targeting the COP9 signalosome for cancer therapy.
Du et al. (2022)
1 more