› 4r2u

X-ray diffraction
2.3Å resolution

Crystal Structure of PPARgamma in complex with SR1664

Released:
DOI: 10.2210/pdb4r2u/pdb
PDB entry 4r2u coloured by chain, front view.
PDB entry 4r2u coloured by chain, side view.
PDB entry 4r2u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Pharmacological repression of PPARγ promotes osteogenesis.
Marciano DP, Kuruvilla DS, Boregowda SV, Asteian A, Hughes TS, Garcia-Ordonez R, Corzo CA, Khan TM, Novick SJ, Park H, Kojetin DJ, Phinney DG, Bruning JB, Kamenecka TM, Griffin PR
Nat Commun 6 7443 (2015)
PMID: 26068133

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, D
Molecule details ›
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 3JX 2 x 3JX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2
Unit cell:
a: 89.63Å b: 63.67Å c: 118.93Å
α: 90° β: 103.43° γ: 90°
R-values:
R R work R free
0.192 0.189 0.248
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Nuclear receptors in podocyte biology and glomerular disease.
Agrawal et al. (2021)
7 more

7 mentions without citation

Pharmacological repression of PPARγ promotes osteogenesis.
Marciano et al. (2015)
6 more