› 4r4h

X-ray diffraction
4.28Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-208504 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Surface protein gp120 Chain: A
Molecule details ›
Chain: A
Length: 433 amino acids
Theoretical weight: 48.98 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q73372 (Residues: 1-13, 14-508; Coverage: 48%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
T-cell surface glycoprotein CD4 Chain: B
Molecule details ›
Chain: B
Length: 178 amino acids
Theoretical weight: 19.73 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01730 (Residues: 26-203; Coverage: 41%)
Gene name: CD4
Sequence domains:
Antibody 2.2c, Light chain Chain: L
Molecule details ›
Chain: L
Length: 210 amino acids
Theoretical weight: 22.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
Antibody 2.2c, Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.7 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 61.357Å b: 69.429Å c: 328.576Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.31 0.309 0.32
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

15 review citations

Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1.
Lewis et al. (2015)
14 more

3 mentions without citation

Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection.
Acharya et al. (2014)
2 more