› 4r7h

X-ray diffraction
2.8Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-139513 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage colony-stimulating factor 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 38.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07333 (Residues: 530-530, 542-919; Coverage: 35%)
Gene names: CSF1R, FMS
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand P31 1 x P31
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P43212
Unit cell:
a: 63.984Å b: 63.984Å c: 185.041Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.221 0.248
Expression system: Spodoptera frugiperda

Quick links

Citations

100 review citations

Tumour-associated macrophages as treatment targets in oncology.
Mantovani et al. (2017)
99 more

11 mentions without citation

An overview of kinase downregulators and recent advances in discovery approaches.
Wang et al. (2021)
10 more