› 4r7l

X-ray diffraction
1.66Å resolution

Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1

Released:
DOI: 10.2210/pdb4r7l/pdb
PDB entry 4r7l coloured by chain, front view.
PDB entry 4r7l coloured by chain, side view.
PDB entry 4r7l coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ouyang P, Cui K, Lu W, Huang J

Function and Biology Details

Reactions catalysed: 
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
Release of the N-terminal residue from a tripeptide.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukotriene A-4 hydrolase Chain: A
Molecule details ›
Chain: A
Length: 631 amino acids
Theoretical weight: 71.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09960 (Residues: 1-611; Coverage: 100%)
Gene names: LTA4, LTA4H
Sequence domains:
Structure domains:

Ligands and Environments

6 bound ligands:
Ligand ZN 1 x ZN
Ligand YB 1 x YB
Ligand GOL 3 x GOL
Ligand ACT 2 x ACT
Ligand IMD 1 x IMD
Ligand SHH 1 x SHH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 77.916Å b: 87.134Å c: 99.285Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.153 0.185
Expression system: Escherichia coli

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