› 4ra8

X-ray diffraction
2.6Å resolution

Structure analysis of the Mip1a P8A mutant

Released:
DOI: 10.2210/pdb4ra8/pdb
PDB entry 4ra8 coloured by chain, front view.
PDB entry 4ra8 coloured by chain, side view.
PDB entry 4ra8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
Liang WG, Ren M, Zhao F, Tang WJ
J Mol Biol 427 1345-1358 (2015)
PMID: 25636406

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145189 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 3 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 69 amino acids
Theoretical weight: 7.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10147 (Residues: 23-91; Coverage: 99%)
Gene names: CCL3, G0S19-1, MIP1A, SCYA3
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6222
Unit cell:
a: 180.154Å b: 180.154Å c: 77.548Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.248
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Hepatic Insulin Clearance: Mechanism and Physiology.
Najjar et al. (2019)
7 more

2 mentions without citation

Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Liang et al. (2016)
1 more