› 4rak

X-ray diffraction
2.04Å resolution

Crystal structure of nuclear receptor subfamily 1, group h, member 2 (lxrb) complexed with partial agonist

Released:
DOI: 10.2210/pdb4rak/pdb
PDB entry 4rak coloured by chain, front view.
PDB entry 4rak coloured by chain, side view.
PDB entry 4rak coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ.
Kick E, Martin R, Xie Y, Flatt B, Schweiger E, Wang TL, Busch B, Nyman M, Gu XH, Yan G, Wagner B, Nanao M, Nguyen L, Stout T, Plonowski A, Schulman I, Ostrowski J, Kirchgessner T, Wexler R, Mohan R
Bioorg Med Chem Lett 25 372-7 (2015)
PMID: 25435151

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-157162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterols receptor LXR-beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 264 amino acids
Theoretical weight: 30.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P55055 (Residues: 213-460; Coverage: 54%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand BU1 3 x BU1
Ligand 652 2 x 652
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: I212121
Unit cell:
a: 55.82Å b: 120.63Å c: 176.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.229 0.271
Expression system: Not provided

Quick links

Citations

5 review citations

Liver X receptors link lipid metabolism and inflammation.
Schulman IG. (2017)
4 more