› 4rbw

X-ray diffraction
1.5Å resolution

Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant)

Released:
DOI: 10.2210/pdb4rbw/pdb
PDB entry 4rbw coloured by chain, front view.
PDB entry 4rbw coloured by chain, side view.
PDB entry 4rbw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Design of a potent antibiotic peptide based on the active region of human defensin 5.
Wang C, Shen M, Gohain N, Tolbert WD, Chen F, Zhang N, Yang K, Wang A, Su Y, Cheng T, Zhao J, Pazgier M, Wang J
J Med Chem 58 3083-93 (2015)
PMID: 25782105

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169582 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HD5(63-94) Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 32 amino acids
Theoretical weight: 3.68 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q01523 (Residues: 63-94; Coverage: 43%)
Gene names: DEF5, DEFA5
Sequence domains: Mammalian defensin

Ligands and Environments

2 bound ligands:
Ligand SO4 9 x SO4
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21
Unit cell:
a: 20.55Å b: 51.703Å c: 50.676Å
α: 90° β: 96.35° γ: 90°
R-values:
R R work R free
0.184 0.182 0.221
Expression system: Not provided

Quick links

Citations

9 review citations

Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections.
Ma et al. (2020)
8 more