› 4rc3

X-ray diffraction
2.34Å resolution

Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives

Released:
DOI: 10.2210/pdb4rc3/pdb
PDB entry 4rc3 coloured by chain, front view.
PDB entry 4rc3 coloured by chain, side view.
PDB entry 4rc3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhang W, Wan X, Huang N

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 289 amino acids
Theoretical weight: 33.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P11309 (Residues: 29-313; Coverage: 91%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 3OA 1 x 3OA
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P65
Unit cell:
a: 97.867Å b: 97.867Å c: 80.832Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.191 0.222
Expression system: Escherichia coli BL21

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