› 4rcw

X-ray diffraction
3.19Å resolution

Crystal structure of human Slitrk1

Released:
DOI: 10.2210/pdb4rcw/pdb
PDB entry 4rcw coloured by chain, front view.
PDB entry 4rcw coloured by chain, side view.
PDB entry 4rcw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion.
Um JW, Kim KH, Park BS, Choi Y, Kim D, Kim CY, Kim SJ, Kim M, Ko JS, Lee SG, Choii G, Nam J, Heo WD, Kim E, Lee JO, Ko J, Kim HM
Nat Commun 5 5423 (2014)
PMID: 25394468

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188682 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SLIT and NTRK-like protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 240 amino acids
Theoretical weight: 27.33 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96PX8 (Residues: 341-580; Coverage: 35%)
Gene names: KIAA1910, LRRC12, SLITRK1, UNQ233/PRO266
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P6122
Unit cell:
a: 69.607Å b: 69.607Å c: 409.946Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.26 0.259 0.298
Expression system: Spodoptera frugiperda

Quick links

Citations

17 review citations

Transcellular Nanoalignment of Synaptic Function.
Biederer et al. (2017)
16 more

2 mentions without citation

Slitrk Missense Mutations Associated with Neuropsychiatric Disorders Distinctively Impair Slitrk Trafficking and Synapse Formation.
Kang et al. (2016)
1 more