› 4rex

X-ray diffraction
1.6Å resolution

Crystal structure of the first WW domain of human YAP2 isoform

Released:
DOI: 10.2210/pdb4rex/pdb
PDB entry 4rex coloured by chain, front view.
PDB entry 4rex coloured by chain, side view.
PDB entry 4rex coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the first WW domain of human YAP2 isoform.
Martinez-Rodriguez S, Bacarizo J, Luque I, Camara-Artigas A
J Struct Biol 191 381-7 (2015)
PMID: 26256245

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155551 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional coactivator YAP1 Chain: A
Molecule details ›
Chain: A
Length: 49 amino acids
Theoretical weight: 5.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P46937 (Residues: 165-209; Coverage: 9%)
Gene names: YAP1, YAP65
Sequence domains: WW domain
Structure domains: Ubiquitin Ligase Nedd4; Chain: W;

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P21212
Unit cell:
a: 42.673Å b: 43.101Å c: 21.302Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.178 0.194
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 citation in other articles

Inferring protein 3D structure from deep mutation scans.
Rollins et al. (2019)
5 more

3 mentions without citation

Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity.
Lin et al. (2019)
2 more